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WHO WE ARE – Cardiawave

Cardiawave was created at the end of 2014 as a result of a partnership of over 6 years between the academic laboratories Physics for Medicine Paris (INSERM/CNRS/ESPCI/PSL) and Langevin Institute (CNRS/INSERM/ESPCI), world leaders in ultrasound imaging and therapy, and the Georges Pompidou European Hospital (HEGP), a leader in the field of valve disease and cardiac ultrasound imaging.

Based at the business incubator of Paris Biotech Santé in Cochin and member of the national research consortium RHU Stop-AS and of the competitiveness cluster MEDICEN Paris Région, Cardiawave employs 26 people and has secured over €22M in funding since its inception.

With a quality management system that is EN ISO 13485:2016 certified since 2019, Cardiawave has developed Valvosoft®, a non-invasive ultrasound therapy medical investigational device for the treatment of calcific aortic stenosis (CAS), the most prevalent heart valve disease in adults and one of the most common causes of cardiovascular mortality worldwide. Cardiawave’s mission is to improve the quality of patient care by offering medical devices for non-invasive therapies.

Early 2019, Cardiawave was granted approval to perform a first-in-human feasibility clinical study (FIH‑I) in France and in the Netherlands enrolling 10 patients. Another study (FIH-II) has been approved in Serbia and started at the end of 2019. In 2020, Cardiawave obtained approval for an extension of its FIH-I increasing the study population up to 30 patients. This study extension is on-going.

A Research Letter presenting the preliminary results of the FIH-I has been published in Circulation on January 25, 2021.


Pulsed Cavitational Ultrasound Softening: a new non-invasive therapeutic approach of calcified bioprosthetic valve stenosis. – Journal of the American College of Cardiology Basic to Translational Science, August 2017.
Villemain O, Robin J, Bel A, Kwiecinski W, Bruneval P, Arnal B, Rémond M, Tanter M, Messas E, Pernot M.
2(4):372-383. DOI: 10.1016/j.jacbts.2017.03.012.

Feasibility and Safety of Non-Invasive Ultrasound Therapy (NIUT) on Porcine Aortic Valve. – Physics in Medicine & Biology, July 2020.
Messas E. et al
DOI 10.1088/1361-6560/aba6d3

Feasibility and Performance of Noninvasive Ultrasound Therapy in Patients With Severe Symptomatic Aortic Valve Stenosis: A First-in-Human Study – Circulation by American Heart Association, January 2021.
Messas E, IJsselmuiden A, Goudot G, Vlieger S, Zarka S, Puymirat E, Cholley B, Spaulding C, Hagège A, Marijon E, Tanter M, Bertrand B, Rémond M, Penot R, Ren B, Den Heijer P, Pernot M, and Spaargaren R
143:00-00. DOI: 10.1161/CIRCULATIONAHA.120.050672

Cardiawave has won
several awards and contests

Contact Us

Awards & Honours

2021 HealthTech Award, best concept / invention
Nobel Project – MedTech Forum 2021

2020 Tech Tour finalists
Tech Tour

2019 “Best Fit to the US market”, pitch contest in Boston
Care Tour

2019 Prize-winner of the International Symposium on Therapeutic Ultrasound: Student Award
ISTU / Barcelona

2018 Prize-winner of Gallien MedStart’Up, in the category: Best Collaboration with Academia Leading to a Breakthrough Solution, partnering with Mount Sinai Medical Center New York

2018 Prize-winner of SME Instrument, Phase 2
European Union

2017 Prize-winner of Worldwide Innovation Contest (CMI), 3rd phase
French government / BPI France

2015 Prize-winner of Worldwide Innovation Contest (CMI), 2nd phase
French government / BPI France

2015 Prize winner of Fondation pour l’Innovation Thérapeutique Béatrice Denys
Turenne Capital (French Investment Fund)

2014 Prize-winner of Worldwide Innovation Contest (CMI), 1st phase
French government / BPI France

2014 Prize-winner of the French National Contest for Innovative Technologies Companies
French government / BPI France


Benjamin Bertrand
Chief Executive Officer
Maurice Delplanque
Chief Operative Officer
Luc Morisset
Quality & Reg. Affairs Director
Dirk Pauwels
Clinical Director

Board of Directors

Emmanuel Blanc
Denis Gestin
Independant Administrator
Armelle Graciet
Director Industrial Affairs SNITEM
Jean De Gunzburg
CSO Da Volterra
François Lefebvre
Business Angel
François Thomas
Independent Administrator

Scientific Advisory Board

Prof. Emmanuel Messas
Head of SAB, Founder, Cardiologist, HEGP
Michael Tanter, PhD
Founder, Physicist, Physics for Medicine Paris
Mathieu Pernot, PhD
Founder, Physicist, Physics for Medicine Paris
Prof. Mathias Fink
Founder, Physicist, Langevin Institute
Prof. Alain Cribier
Cardiologist & TAVR Inventor
Prof. Ehud Schwammenthal
Cardiologist & CMO Magenta
Dr. Robert Levine
Cardiologist, MGH
Dr Roxana Mehran
Cardiologist, Mount Sinai Hospital New York


Véronique Asty
Office Manager
Alexandre Brand
SW Engineer
Aurélien Corbel
Embedded System & Real Time Lead Senior Architect
Matthieu Dumoulin
Mechanical R&D Engineer
Camille Fayand
Integration & Validation Engineer
Ana Fouquier
SW Arch. & Image Processing Manager
Claude Goubet
Medical Imaging R&D Engineer
Nan Kang
SW Engineer
Wojciech Kwiecinski
Ultrasound R&D Engineer
Zahir Larabi
Test A. & Validation Manager
Pidio Lys
HW Manager
Eric Noël
Electronics R&D Director
Robin Penot
Preclinical R&D Engineer
Clémence Pupier
Quality & Reg. Affairs PM
Mathieu Rémond
Preclinical PM
Claire Réty
Test & Validation Engineer
Thomas Souyris
Mechanical R&D Manager
Daniel Suarez
Ultrasound R&D Engineer
Amel Korso-Feciane
Test Bench Engineer
Imane Errabie
Quality & Regulatory Affairs Assistant
Audran Caron
System Engineer
Loïc Razafilahy
Software Engineer in Test
Afaq Shafeeq
Test & Validation Engineer
Nathan Kabasela Kabasele
Stock Operator
Hélène Gotteland
Communication & Event Assistant